Table 3.
Plasma protein concentrations by neutropenia statusa
| Total population | No exogenous G-CSFb | |||||
|---|---|---|---|---|---|---|
| Plasma protein | Non-neutropenic (n = 216) |
Neutropenic (n = 29) | p c | Non-neutropenic (n = 212) |
Neutropenic (n = 13) |
p c |
| ANG2 (pg/ml) | 8242 (4039, 16694) | 9165 (2708, 17244) | 0.65 | 8252 (3918, 16694) | 9475 (3168, 18936 | 0.68 |
| IL1RA (pg/ml) | 1269 (243, 5202) | 1049 (103, 5329) | 0.77 | 1346 (249, 3205) | 534 (198, 3717) | 0.52 |
| IL-6 (pg/ml) | 249 (76, 752) | 457 (181, 1117) | 0.03 | 249 (75, 773) | 457 (281, 1117) | 0.11 |
| IL-8 (pg/ml) | 94 (27, 600) | 581 (358, 1576) | <0.01 | 93 (27, 600) | 478 (361, 1681) | <0.01 |
| G-CSF (pg/ml) | 99 (29, 474) | 3624 (919, 10099) | <0.01 | 90 (33, 331) | 6660 (3411, 9045) | <0.01 |
G-CSF granulocyte colony-stimulating factor, ANG2 angiopoietin 2, IL1RA interleukin-1 receptor antagonist, IL-6 interleukin-6, IL-8 interleukin-8
aData are displayed as median (interquartile range)
bExcluding subjects who received exogenous G-CSF within 30 days of enrollment
cPlasma protein levels were compared between neutropenic and non-neutropenic using the Wilcoxon rank-sum test