Figure 1.

(A-B) FKBP51 expression in healthy colon: (A) Positive staining in enterocytes and cells of the lamina propria; (B) in healthy colon, few cells in Auerbach's plexus exhibit a weak signal. (C) By contrast, in colorectal cancer tissue sections, positive staining is observed in several cells of the plexus. (D-G) FKBP51 expression in colon adenocarcinoma: Tumor cells and inflammatory and fibrous stromal cells exhibit variable signals, from (D) strongly positive to (E) absent. (F) Magnification of (D), showing immature phenotype of stromal fibroblasts surrounding a lesion with positive FKBP51 cells. (G) Magnification of (E), showing mature phenotype of stromal fibroblasts surrounding a lesion with cells completely negatively expressing FKBP51. FKBP51, FK506-binding protein 5.