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. 2016 Jun 8;12(2):977–982. doi: 10.3892/ol.2016.4685

Figure 1.

Figure 1.

(A) Lane 1, polymerase chain reaction product of NF2 in human Schwann cells. (B) Partial sequence of AS NF2. The arrow indicates the splicing site. (C) The translational consequence of NF2 alternative splicing transcripts. Previously identified COOH-terminal isoforms I and II resulting from alternative splicing of exons 15, 16 and 17. The novel AS isoform contains the first 10 exons and connects to exon 17. The COOH-terminus of the novel AS isoform differs from isoform I and II. The number of residues contained in each polypeptide is indicated. * indicates the Merlin COOH-terminus. M, DNA marker DL2000; AS, alternative splicing.