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. 2016 Jun 23;12(2):1519–1524. doi: 10.3892/ol.2016.4774

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Figure 4. — Immunohistochemical analysis of the expression of T cell Ig and mucin domain-containing molecule-3 (TIM-3) and macrophage markers in adult T-cell leukemia/lymphoma (ATLL) tissues. (A) Representative immunostaining of the macrophage/monocyte markers cluster of differentiation (CD)68 and CD163, and of TIM-3, in ATLL tissue of a TIM-3-negative (Pt.1) and a TIM-3-positive (Pt.2) patient. (B) Representative double-immunostaining of TIM-3 and Iba-1 (a pan-macrophage marker). (C) Survival rate of TIM-3-negative and -positive cases analyzed by Kaplan-Meier analysis. (D) The association between TIM-3 expression and tumor macrophage infiltration.