Table 2. Average hospitalization rates, relative hospitalization rates and absolute excess rates in CCS and matched reference persons.
CCSa | Matched reference personsb | ||||||
---|---|---|---|---|---|---|---|
Hospitalizations | Hospitalization rate per 1000 py at risk | Hospitalizations | Hospitalization rate per 1000 py at risk | RHR | 95%CI | AER per 1000 py at risk | |
All individuals | 1736 | 172.4 | 13765 | 79.1 | 2.2 | 1.9–2.5 | 93.3 |
Gender | |||||||
Male | 693 | 129.5 | 4876 | 53.1 | 2.4 | 2.0–3.0 | 76.4 |
Female | 1043 | 221.0 | 8889 | 108.2 | 2.0 | 1.7–2.4 | 112.8 |
Primary cancer diagnosis | |||||||
Leukemia/lymphoma | 530 | 120.0 | 5536 | 72.8 | 1.6 | 1.4–2.0 | 46.7 |
CNS | 184 | 264.3 | 939 | 77.2 | 3.4 | 2.7–4.4 | 187.1 |
Sarcomas | 369 | 185.9 | 3224 | 90.8 | 2.0 | 1.5–2.8 | 95.1 |
Other solid tumors | 563 | 210.1 | 3631 | 79.3 | 2.6 | 2.0–3.5 | 130.8 |
Other and unspecified cancers | 90 | 329.8 | 435 | 98.0 | 3.4 | 2.0–5.5 | 231.8 |
Recurrences of primary cancer before five-year survival | |||||||
None | 1436 | 159.8 | 11995 | 78.6 | 2.0 | 1.8–2.4 | 81.2 |
Any | 300 | 277.2 | 1770 | 82.9 | 3.3 | 2.5–4.5 | 194.3 |
Cancer treatmentc, d | |||||||
No chemotherapy or radiotherapy | 180 | 219.5 | 1255 | 88.6 | 2.5 | 1.5–4.1 | 130.9 |
Chemotherapy | 614 | 119.0 | 6020 | 67.8 | 1.8 | 1.4–2.2 | 51.2 |
Radiotherapy | 240 | 344.6 | 1188 | 102.0 | 3.4 | 2.2–5.0 | 242.7 |
Chemotherapy and radiotherapy | 701 | 206.9 | 5298 | 89.4 | 2.3 | 2.0–2.7 | 117.6 |
a Time at risk in CCS was censored at the date of five-year survival in case of ongoing primary cancer recurrence treatment or at the incidence date of first primary cancer recurrence after the date of five-year survival.
b Up to 20 reference persons were sampled per survivor and categorized into cancer diagnosis and treatment groups according to the corresponding CCS
c Cancer treatment groups were mutually exclusive, i.e. persons could contribute to one cell only. Treatment categories were irrespective of surgical treatment.
d We took all cancer treatment that was given before the date of five-year survival into account.
Abbreviations: CCS: childhood cancer survivors; py: person years; RHR: relative hospitalization rate; CI: confidence interval; AER: absolute excess rate.