Table 1. Pre-erythrocytic antigens selected for vaccine evaluation.
| Pf Name | Py ortholog | Pb ortholog | Protein Function | A.A. boundaries in vaccine | |
|---|---|---|---|---|---|
| Py | Pb | ||||
| PF3D7_0304600 (CSP) | PY03168 | PBANKA_040320 | Circumsporozoite (CS) protein (CSP) | 35–380 | 21–320 |
| PF3D7_0730200a | PY03000 | PBANKA_021430 | Adapter-related protein | 6–891 | 5–892 |
| PF3D7_1323000a | PY01586 | PBANKA_133820 | Beta-hydroxyacyl-ACP dehydratase (FabZ) | 8–231 | 1–229 |
| PF3D7_1411500a | PY00162 | PBANKA_103100 | Conserved Plasmodium protein, unknown function | 3–980 | 302–942 |
| PF3D7_1418100 (LISP1)a | PY04499 | PBANKA_102460 | Liver specific protein 1, putative (LISP1) | 25–607, 600–1178, and 1172–1732 | 28–601 and 2579–3254 |
| PF3D7_1207400a | PY04162 | PBANKA_060590 | Conserved Plasmodium protein, unknown function | 1–387 | 153–348 |
| PF3D7_1241500a | PY01495 | PBANKA_145490 | Conserved Plasmodium protein, unknown function | 1–467 | 1–298 |
| PF3D7_1308500b | PY04905 | PBANKA_140700 | Conserved Plasmodium protein, unknown function | 14–453 | 319–456 |
| PF3D7_0727200b | PY02096 | PBANKA_021130 | Cysteine desulfurase, putative (NFS) | 3–559 | 1–541 |
| PF3D7_0818900b | PY06158 | PBANKA_071190 | Heat shock 70 KDa protein, (HSP70) | 1–682 | 1–693 |
| PF3D7_1111200b | PY02705 | PBANKA_093640 | Conserved Plasmodium protein, unknown function | 1–360 | 122–553 |
| PF3D7_1122200b | PY05603 | PBANKA_092610 | Cupin-like protein, putative | 63–350 | 63–447 |
| PF3D7_1134000b | PY06981 | PBANKA_091440 | Heat shock protein 70 (Hsp70-3) | 1–663 | 250–553 |
| PF3D7_1147000 (SLARP)b | PY03269 | PBANKA_090210 | Sporozoite and liver asparagine-rich protein (SLARP) | 1356–1989 and 2554–2599 | 2877–3218 |
| PF3D7_1302200b | PY03011 | PBANKA_140080 | Early transcribed membrane protein 13 (ETRAMP13) | 21–215 | 1–209 |
| PF3D7_1434400b | PY03139 | PBANKA_101040 | Conserved Plasmodium membrane protein, unknown function | 1–264 | 29–261 |
| PF3D7_1456100b | PY00669 | PBANKA_131980 | Serine hydroxymethyltransferase, putative (SHMT) | 1–484 | 5–484 |
| PF3D7_0103400b | PY03811 | PBANKA_020970 | Zinc-carboxypeptidase, putative | 623–1203 and 1214–1563 | N/A |
| PF3D7_0304300b | PY03529 | PBANKA_040290 | Conserved Plasmodium protein, unknown function | 15–754 | 1–612 |
| PF3D7_0405500b | PY01668 | PBANKA_100320 | Conserved Plasmodium protein, unknown function | 1–198 | 1–199 |
| PF3D7_0506200b | PY00712 | PBANKA_110580 | Transcription initiation factor TFiid, TATA-binding protein (TBP) | 1–277 | 35–281 |
| PF3D7_1026400c | PY07496 | PBANKA_051060 | Cell division cycle protein 20 homolog, putative (CDC20) | 291–552 | 1–538 |
aProtective in both models
bProtective in one model
cProtective in neither model
CSP as a positive control.