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. 2016 Jul 19;14(7):e1002511. doi: 10.1371/journal.pbio.1002511

Fig 7. WFS1 deficiency is associated with reduced volume of the optic nerve, brain stem, and cortex at the level of the striatum.

Fig 7

(A–D) Brains, within skulls, were scanned ex vivo using a 94/20 Bruker BioSpec MRI. Representative single coronal slice from the imaging sequence (A, C) and a 3D reconstruction of the brain stem (B, D). The outer skull, tissue, and surrounding medium have been removed for clarity. (E–H) Volumetric analysis of brains from Wfs +/+ and -/- male mice: whole brain (E), optic nerve (F), brain stem (G), and cortical volumes at the level of striatum (H). *p < 0.05 and **p < 0.01 compared with Wfs +/+, groups (n = 4 animals in each group).