Table 3.

Unanswered questions regarding ZIKV infection and neuropsychiatric complications

What are the mechanisms underlying ZIKV-induced neuronal damage?

What is the role of the immune response against ZIKV in the pathogenesis of neurological complications?

What are the risk and protective factors related to the development of neurological complications after ZIKV infection?

Are there differences in ZIKV infection during the first trimester of pregnancy according to maternal immune response and/or viral load?

Is there any neurological and/or psychiatric consequence for the fetus of ZIKV infection in the second half of pregnancy?

Is the ZIKV infection associated with other immune-mediated neurological diseases?

Abbreviation: ZIKV, Zika virus.