Table 2. Metabolites associated with body mass index in American Indians.
| Matching metabolites | Class | Adduct type | Theoretical m/z | Experimental m/z | Δ ppma | Retention time(s) | Confidence level | Model 1b | Model 2b | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| β (95% CI)c | P value | Β (95% CI)c | P value | ||||||||
| Positively associated metabolites | |||||||||||
| Oleoylethanolamide | Fatty amides | M+H | 326.3053 | 326.3043 | 3 | 490 | Level 5 | 0.12 (0.05, 0.18) | 4.46×10−4 | 0.13 (0.02, 0.24) | 5.77×10−4 |
| Kynurenine | Amino acids | M+H | 209.0921 | 209.0909 | 5 | 45 | Level 1d | 0.12 (0.05, 0.19) | 1.03×10−4 | 0.13 (0.06, 0.20) | 1.83×10−4 |
| Auxin A | Prenol lipids | M+H | 329.2323 | 329.2319 | 1 | 29 | Level 5 | 0.15 (0.07, 0.22) | 1.13×10−4 | 0.14 (0.07, 0.21) | 2.28×10−4 |
| 12-Ketoporrigenin | Steroid derivatives | M+Na | 469.2924 | 469.2879 | 9 | 496 | Level 5 | 0.18 (0.07, 0.28) | 8.47×10−5 | 0.15 (0.07, 0.23) | 4.22×10−4 |
| Combined effect | 0.12 (0.07, 0.17) | 4.41×10−6 | 0.13 (0.08, 0.18) | 1.86×10−6 | |||||||
| Negatively associated Metabolites | |||||||||||
| Mannosyl-diinositol-phosphorylceramide | Sphingolipids | M+H | 1,358.7725 | 1358.7724 | 1 | 210 | Level 5 | -0.13 (-0.21,-0.06) | 3.01×10−5 | -0.12 (-0.18,-0.06) | 2.28×10−4 |
a Delta in parts per million.
b Model 1 adjusted for age, sex, site, lifestyle (smoking, alcohol drinking, and physical activity), and socioeconomic status (education level); Model 2 further adjusted for dietary caloric, protein, and fat intakes and HOMA-IR.
c Change in BMI per SD change in log-ransformed abundance of metabolites.
d Previously validated with standard and MS/MS.