Table 1.
Hierarchical Linear Regressions of Polygenic Risk Score and Lifetime Trauma Exposure Predicting Cognitive Functioning
| Inhibitory Control
|
Working Memory
|
Episodic Memory
|
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|---|---|---|---|---|---|---|---|---|---|
| β/SE | P-value | R2 | β/SE | P-value | R2 | β/SE | P-value | R2 | |
|
|
|
|
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| Block 1 | 2.1% | 14.0% | 4.5% | ||||||
| Age | .05/0.01 | .52 | .06/0.01 | .37 | −.01/0.01 | .90 | |||
| Sex | .05/0.20 | .50 | −.14/0.17 | .06 | −.04/0.25 | .59 | |||
| Est. IQ | −.07/0.01 | .37 | .33/0.00 | <.001 | .21/0.01 | .007 | |||
| PC1 | .07/0.87 | .37 | −.04/0.75 | .62 | .04/1.09 | .60 | |||
| PC2 | −.02/0.86 | .84 | −.04/0.74 | .62 | .02/1.08 | .80 | |||
| PC3 | −.09/0.88 | .27 | .08/0.75 | .28 | −.04/1.10 | .64 | |||
|
|
|
|
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| Block 2 | 3.8% | 0.7% | 0.0% | ||||||
| Polygenic Score | −.20/0.53 | .009 | .09/0.46 | .23 | .01/0.67 | .92 | |||
|
|
|
|
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| Block 3 | 0.5% | 0.0% | 0.1% | ||||||
| Trauma Exposure | −.07/0.02 | .34 | .01/0.2 | .95 | .03/0.03 | .75 | |||
|
|
|
|
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| Block 4 | 0.9% | 5.1% | 0.0% | ||||||
| Polygenic Score x Trauma Exposure | .59/0.19 | .19 | −1.38/0.16 | .001 | .07/0.24 | .88 | |||
Note. Est. IQ = Estimated intelligence quotient from Wechsler Test of Adult Reading (Wechsler, 2001). PC = principal component. Trauma exposure = total types of different traumas over the lifespan. R2 = R2 change for blocks 2–4.