Table 1.
Summary of Candidate Genes Studied in Relation to Posttraumatic Stress Disorder*
| Gene | Common name(s) | Location | Total Number of Published Reports | Significant Findings | Null Findings |
|---|---|---|---|---|---|
| RD2 (D2R, D2DR) | Dopamine receptor DR | 11q23 | 6 | 4 | 2 |
| DRD4 (D4DR) | Dopamine receptor D4 | 11p15.5 | 1 | 1 | 0 |
| SLC6A3 (DAT1) | Dopamine transporter | 5p15.3 | 4 | 3 | 1 |
| DBH | Dopamine beta-hydroxylase | 9q34 | 1 | 0 | 1 |
| SLC6A4 (HTT, 5HTT, SERT, 5- HTTLPR) | Serotonin transporter | 17q11 | 16 | 12 | 4 |
| HTR2 (5-HT2A) | 5-hydroxytryptamine (serotonin) receptor 2A | 13q14-q21 | 1 | 1 | 0 |
| FKBP5 | FK506 binding protein 5 | 6p21 | 4 | 4 | 0 |
| GCCR (NR3C1) | Glucocorticoid receptor | 5q31.3 | 1 | 0 | 1 |
| CRHR1 | Corticotropin-releasing hormone receptor 1 | 17q12-22 | 1 | 1 | 0 |
| RGS2 | Regulator of G-protein signaling 2 | 1q31 | 1 | 1 | 0 |
| CNR1 (CB1, CNR) | Cannabinoid receptor 1 (brain) | 6q14-q15 | 1 | 0 | 1 |
| APOE | Apolopoprotein E | 19q13 | 1 | 1 | 0 |
| BDNF | Brain-derived neurotrophic factor | 11p13 | 3 | 0 | 3 |
| NPY | Neuropeptide Y | 7p15.1 | 1 | 0 | 1 |
| GABRA2 | GABAA | 4p12 | 1 | 1 | 0 |
| COMT | Catechol-O-methyltransferase | 22q11 | 2 | 2 | 0 |
| ADCYAP1R1 | Receptor for adenylate cyclase-activating polypeptide 1 | 7p14 | 2 | 1 | 1 |
| DTNBP1 | Dystrobrevin-binding protein 1 | 6p22 | 1 | 1 | 0 |
| CRNA5 | Cholinergic receptor, neuronal nicotinic, alpha polypeptide 5 | 15q25.1 | 2 | 1 | 1 |
| PRKCA | Protein kinase C alpha | 17q22-q23.2 | 1 | 1 | 0 |
| TPH1 | Tryptophan hydroxylase 1 | 11p15.3-p14 | 1 | 1 | 0 |
| TPH2 | Tryptophan hydroxylase 2 | 12q21.1 | 1 | 1 | 0 |
*
A referenced version of this Table appears as Table 1S in Supplemental Material.