Table 1.
Sudden cardiac arrhythmia | Genes |
---|---|
Long QT Syndrome (LQTS) | KCNQ1, KCNH2, SCN5A, ANK2, KCNE1, KCNE2, KCNJ2, CACNA1C, CAV3, SCN4B, AKAP9, SNTA1, KCNJ5 |
Brugada Syndrome (BrS) | SCN5A, GPD1L, CACNA1C, CACNB2, SCN1B, KCNE3, SCN3B, KCND3, KCNJ8 |
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) | RYR2, CASQ2, ANK2, KCNJ2, TRDN |
WPW Syndrome | PRKAG2 |
Short QT Syndrome (SQTS) | KCNH2, KCNJ2, CACNA1C, CACNB2, KCNQ1 |
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) | DSC2, DSG2, TMEM43, PKP2, DSP, RYR2, JUP, RPSA, TGFB3 |
Sick sinus syndrome (SSS) | SCN5A, HCN4 |
Cardiac conduction disease (CCD) | SCN5A |
Hypertrophic Cardiomyopathy (HCM) | MYH7, MYBPC3, TNNT2, TNNI3, TPM1, ACTC1, MYL2, MYL3, MYH6, LAMP2, PRKAG2, CSRP3, GLA, VCL, TNNC1, TTR, TTN, TCAP, MYLK2, MYOZ2, MYO6 |
Dilated cardiomyopathy (DCM) | DES, TNNT2, MYH7, CSRP3, PLN, TCAP, ABCC9, LMNA, DMD, TAZ, TTN, VCL, EYA4, EMD, ACTN2, SGCD, ACTC1, TNNI3, TPM1, MYBPC3, LDB3, MYH6, CTF1, ANKRD1 |
Dilated cardiomyopathy with Cardiac conduction defect (DCM+CCD) | SCN5A, LMNA |
Left ventricular noncompaction (LVNC) | LDB3, TAZ, MYH7, MYBPC3, ACTC1, TNNT2, SCN5A, LMNA, DMPK, DTNA, AMPD1, PMP22, LMX1B, YWHAE |
Restrictive cardiomyopathy (RCM) | MYH7, TNNI3, TNNT2 |
Atrial Fbrillation (AF) | KCNQ1, KCNE2, KCNJ2, KCNH2, SCN5A, KCNA5, NPPA, NUP155, GJA5, ABCC9, GATA4, GATA5, GATA6, KCNE1L |
Different types of sudden cardiac arrhythmia share the same pathogenic gene.