Figure 3.

Specific receptor tyrosine kinases require clathrin for activation of Gab1-Akt signaling upon ligand binding. Shown is a diagram depicting EGFR homodimers and Met as RTKs that require plasma membrane clathrin signaling microdomains for the phosphorylation of Gab1 leading to activation of phosphatidylinositol-3-kinase (PI3K)-Akt signaling. The phosphorylation of Gab1 may require a clathrin microdomain-enriched kinase. In contrast, EGFR-ErbB2 heterodimers do not require clathrin signaling microdomains for activation of Gab1-PI3K-Akt signaling.