Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 12;9(3):e1125053. doi: 10.1080/19420889.2015.1125053

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

PMC Copyright notice

Figure 1. — The role of MIM during dendritic filopodia initiation. (A) MIM domain structure. (B) A schematic representation of an MIM monomer, which dimerizes via its I-BAR domain. The central region contains polyproline stretches and sites that are modified post-translationally. The C-terminus contains an ATP-actin binding WH2 domain. (C-E) The upper panel displays time frames of initiating dendritic filopodia and below is a schematic summary of each stage according to our findings.³ (C) phosphoinositide-dependent recruitment of MIM results in its site-specific oligomerization and (D) outward membrane bending. (E) The subsequent elongation of the protrusion requires Arp2/3-mediated actin assembly. Scale bar 0.5 μm.