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. 2016 Mar 19;7(14):17410–17414. doi: 10.18632/oncotarget.8202

Table 2. Overlapped pathways identified in T2D and MDD.

Term Total pathway size Number of genes modulated by overlapped SNPs Benjamini-corrected p-value Genes
ECM-receptor interaction 2 2 1.36E-05 HSPG2, COL4A2
Glycerolipid metabolism 8 3 5.46E-05 PPAP2B, DGKB, LIPC
Glycerophospholipid metabolism 8 3 5.46E-05 PPAP2B, DGKB, ACHE
Ether lipid metabolism 2 1 1.36E-05 PPAP2B
Sphingolipid metabolism 2 1 1.36E-05 PPAP2B
Fc gamma R-mediated phagocytosis 3 2 2.05E-05 PPAP2B DNM3
Cytokine-cytokine receptor interaction 4 4 2.73E-05 LEPR, TGFB2, IL2RA, CCL11
Neuroactive ligand-receptor interaction 6 6 4.09E-05 LEPR, PTGER3, GABRB1, GRM8, LPAR2, GRIK1
Jak-STAT signaling pathway 3 3 2.05E-05 LEPR, SPRED2, IL2RA
Adipocytokine signaling pathway 2 2 1.36E-05 LEPR, PPARGC1A
Calcium signaling pathway 5 4 3.41E-05 PTGER3, SLC8A1, CACNA1C, ITPR2
Cell adhesion molecules 3 2 2.05E-05 NEGR1, CNTN1
Wnt signaling pathway 7 6 4.77E-05 VANGL1, PRICKLE2, CTBP2, SMAD3, NFATC3, NFATC2
Dorso-ventral axis formation 2 2 1.36E-05 NOTCH2, ETV6
Notch signaling pathway 2 2 1.36E-05 NOTCH2, CTBP2
Endocytosis 4 4 2.73E-05 DNM3, IL2RA, USP8, GIT1
MAPK signaling pathway 6 6 4.09E-05 TGFB2, MRAS, MAP4K2, CACNA1C, FGF14, NFATC2
Cell cycle 5 3 3.41E-05 TGFB2, E2F3, SMAD3
TGF-beta signaling pathway 3 2 2.05E-05 TGFB2, SMAD3
Pathways in cancer 11 9 7.5E-05 TGFB2, PPARG, E2F3, CTBP2, IGF1, FGF14, COL4A2, SMAD3, DCC
Colorectal cancer 4 3 2.73E-05 TGFB2, SMAD3, DCC
Pancreatic cancer 5 3 3.41E-05 TGFB2, E2F3, SMAD3
Chronic myeloid leukemia 6 4 4.09E-05 TGFB2, E2F3, CTBP2, SMAD3
Hypertrophic cardiomyopathy 7 6 4.77E-05 TGFB2, SLC8A1, TTN, ACTB, CACNA1C, IGF1
Dilated cardiomyopathy 7 6 4.77E-05 TGFB2, SLC8A1, TTN, ACTB, CACNA1C, IGF1
O-Glycan biosynthesis 2 2 1.36E-05 GALNT2, C1GALT1
Cardiac muscle contraction 3 2 2.05E-05 SLC8A1, CACNA1C
Arrhythmogenic right ventricular cardiomyopathy 5 4 3.41E-05 SLC8A1, ACTB, CACNA1C, PKP2
Ubiquitin mediated proteolysis 2 2 1.36E-05 FANCL, UBE2R2
PPAR signaling pathway 2 2 1.36E-05 PPARG, EHHADH
Huntington's disease 5 4 3.41E-05 PPARG, DNAH1, PPARGC1A, CREB5
Valine, leucine and isoleucine biosynthesis 2 2 1.36E-05 LARS2, EHHADH
Aminoacyl-tRNA biosynthesis 2 2 1.36E-05 LARS2, CARS
Axon guidance 6 6 4.09E-05 ROBO2, UNC5C, ABLIM1, NFATC3, DCC, NFATC2
Tight junction 3 3 2.05E-05 MRAS, ACTB, SYMPK
Regulation of actin cytoskeleton 4 4 2.73E-05 MRAS, ACTB, FGF14, GIT1
Insulin signaling pathway 2 2 1.36E-05 PPARGC1A, GCK
Lysosome 3 3 2.05E-05 MANBA, IGF2R, CTSZ
Glioma 2 2 1.36E-05 E2F3, IGF1
Prostate cancer 3 3 2.05E-05 E2F3, CREB5, IGF1
Melanoma 4 3 2.73E-05 E2F3, IGF1, FGF14
Bladder cancer 2 1 1.36E-05 E2F3
Small cell lung cancer 3 2 2.05E-05 E2F3, COL4A2
Non-small cell lung cancer 2 1 1.36E-05 E2F3
Chondroitin sulfate biosynthesis 2 2 1.36E-05 DSE, CSGALNACT1
Focal adhesion 3 3 2.05E-05 ACTB, IGF1, COL4A2
Adherens junction 4 3 2.73E-05 ACTB, PTPRB, SMAD3
Vibrio cholerae infection 5 2 3.41E-05 ACTB, KCNQ1
Phosphatidylinositol signaling system 6 2 4.09E-05 DGKB, ITPR2
Type II diabetes mellitus 2 2 1.36E-05 GCK, CACNA1C
Maturity onset diabetes of the young 3 3 2.05E-05 GCK, HNF1A, HNF4A
Vascular smooth muscle contraction 2 2 1.36E-05 CACNA1C, ITPR2
Long-term potentiation 2 2 1.36E-05 CACNA1C, ITPR2
GnRH signaling pathway 2 2 1.36E-05 CACNA1C, ITPR2
Alzheimer's disease 2 2 1.36E-05 CACNA1C, ITPR2
Oocyte meiosis 2 2 1.36E-05 ITPR2, IGF1
Long-term depression 2 2 1.36E-05 ITPR2, IGF1
VEGF signaling pathway 2 2 1.36E-05 NFATC3, NFATC2
Natural killer cell mediated cytotoxicity 2 2 1.36E-05 NFATC3, NFATC2
T cell receptor signaling pathway 2 2 1.36E-05 NFATC3, NFATC2
B cell receptor signaling pathway 2 2 1.36E-05 NFATC3, NFATC2