Table 3. Concordance between biopsy, primary tumor and corresponding disseminated lymph nodes and distant metastases in patients with breast cancer and NSCLC.

Degree of concordance	Breast cancer patients No. (%)	NSCLC patients, adenocarcinoma No. (%)	NSCLC patients, SCC, No. (%)
Concordance of FRα status
Biopsy = Primary tumor	27 out of 40 (67.5)	10 out of 12 (83)	10 out of 11 (91)
Primary tumor = Local metastasis	12 out of 20 (60)	31 out of 42 (78)*	13 out of 18 (80)*
Primary tumor = Distant metastases		12 out of 15 (80)	7 out of 8 (88)
Disconcordance of FRα status
Biopsy > Primary tumor	2	1	0
Biopsy < Primary tumor	11	1	1
Primary tumor > Local metastasis	6	4	2
Primary tumor < Local metastasis	2	0	3
Primary tumor > Distant metastasis		2	1
Primary tumor < Distant metastasis		1	0

Abbreviations: SCC squamous cell carcinoma; FRα Folate receptor α; pos LN positive lymph node * LN expression was assessed in 33 patients, in respectively 18 patients with adenocarcinoma and 15 patients with SCC; concordance was seen in 14 out of 18 adenocarcinoma patients (31/42 LNs) and 12 out of 15 SCC patients (13/18 LNs).