. 2016 Mar 17;7(14):17455–17467. doi: 10.18632/oncotarget.8159

Table 1. Summary of P₄−induced phenotypes in the female reproductive tract¹.

	Apoptosis				Proliferation				N/C ratio²				K10 expression				Alcian blue staining & hydropic degeneration				Keratinization
	Cervix/Vagina		Uterus		Cervix/Vagina		Uterus		Cervix		Vagina		Cervix		Vagina		Cervix		Vagina		Cervix		Vagina
Treat.	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄	E₂	E₂+P₄
Pgr^f/f	+	++	++	+	++	+	++	+	+	++	+	++	++	+	++	+	−	++	−	+	−	−	++	−
Pgr^ed/ed	+	+	++	+	++	++	++	+	+	++	+	+	++	+	++	++	−	−	−	−	−	−	++	++

Shown are phenotypes in epithelial PR–sufficient (Pgrf/f) and –deficient (Pgred/ed) mice treated with E₂ and E₂+P₄. 2Nucleus to cytoplasm ratio. ++, high; +, low; −, rare/absent.

Table 1. Summary of P4−induced phenotypes in the female reproductive tract1.

Table 1. Summary of P₄−induced phenotypes in the female reproductive tract¹.