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. 2016 Feb 8;7(14):17631–17640. doi: 10.18632/oncotarget.7268

Figure 2. Genomic structure of DARPP-32 and its truncated isoform, t-DARPP.

Figure 2

DARPP-32 and t-DARPP share identical sequence from exon 2 to the 3′ end. Of note, exon 1 of t-DARPP is spliced from the intron 1 of DARPP-32. DARPP-32 (1,983 bp) encodes 204 amino acids, whereas t-DARPP (1,502 bp) encodes 168-amino-acids protein. The major phosphorylation sites on the proteins are indicated by T, threonine, and S, serine. DARPP-32 contains five phosphorylation sites at T34, S45, T75, S102, and S137, whereas t-DARPP lacks the T34 phosphorylation site of DARPP-32. The scheme is based on [39].