Table 1. Immunohistochemical scoring of marker expression in patient tissue samples.
| Target | Tissue type | Patient Tissue Samples (n) | Pathology Score | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 6 | 9 | % ≥ 4 | |||
| CLDN1 | Normal | 25 | 1 | 1 | 8 | 15 | 0 | 0 | 0 | 0 |
| Normal mucinous† | 25 | 0 | 12 | 13 | 0 | 0 | 0 | 0 | 0 | |
| Adenoma | 24 | 1 | 0 | 0 | 4 | 0 | 15 | 4 | 79 | |
| Adenocarcinoma | 80 | 0 | 0 | 6 | 20 | 8 | 28 | 18 | 68 | |
| GPR56 | Normal | 13 | 0 | 0 | 1 | 1 | 0 | 11 | 0 | 85 |
| Normal mucinous† | 13 | 0 | 1 | 5 | 7 | 0 | 0 | 0 | 0 | |
| Adenoma | 21 | 0 | 0 | 0 | 4 | 0 | 8 | 9 | 81 | |
| Adenocarcinoma | 68 | 0 | 0 | 0 | 13 | 0 | 18 | 37 | 81 | |
| GRM8 | Normal | 23 | 0 | 0 | 0 | 17 | 0 | 6 | 0 | 26 |
| Normal mucinous† | 23 | 0 | 3 | 11 | 6 | 3 | 0 | 0 | 13 | |
| Adenoma | 22 | 0 | 0 | 3 | 5 | 0 | 8 | 6 | 63 | |
| Adenocarcinoma | 75 | 0 | 0 | 10 | 26 | 4 | 29 | 6 | 52 | |
| LY6G6D/F | Normal | 11 | 0 | 0 | 0 | 7 | 0 | 4 | 0 | 36 |
| Normal mucinous† | 11 | 0 | 0 | 9 | 3 | 1 | 0 | 0 | 8 | |
| Adenoma | 16 | 0 | 0 | 0 | 2 | 2 | 6 | 6 | 88 | |
| Adenocarcinoma | 59 | 0 | 0 | 9 | 16 | 1 | 20 | 13 | 58 | |
| SLCO1B3 | Normal | 16 | 3 | 9 | 2 | 1 | 0 | 1 | 0 | 6 |
| Normal mucinous† | 16 | 2 | 11 | 2 | 0 | 1 | 0 | 0 | 6 | |
| Adenoma | 22 | 2 | 1 | 8 | 9 | 0 | 2 | 0 | 9 | |
| Adenocarcinoma | 75 | 8 | 12 | 34 | 16 | 0 | 5 | 0 | 7 | |
| TLR4 | Normal | 14 | 0 | 0 | 11 | 2 | 0 | 0 | 0 | 0 |
| Normal mucinous† | 14 | 0 | 3 | 10 | 0 | 1 | 0 | 0 | 7 | |
| Adenoma | 16 | 0 | 0 | 2 | 4 | 0 | 8 | 2 | 63 | |
| Adenocarcinoma | 60 | 2 | 0 | 16 | 15 | 1 | 20 | 6 | 45 | |
†
Normal mucinous marker expression is scored in epithelial cells of non-neoplastic (normal) colon tissue while considering heterogeneity of expression on the cell surface due to areas of mucinous secretion that do not express marker.