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. 2016 Feb 20;7(14):17805–17814. doi: 10.18632/oncotarget.7525

Figure 4. miR-222 directly targets PTEN for activating several downstream signal molecules.

Figure 4

(A and B) PTEN wild-type and mutant 3′-UTR region reporter activities were assayed as in the Methods. Data are presented as mean ± SE. **indicates significant difference compared to those of control cells (P < 0.01). (C) The levels of PTEN protein and its several downstream signal proteins in these cells were determined using Western blotting at 48 h after the transfection. Representative blotting images are shown.