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. 2016 Feb 20;7(14):17805–17814. doi: 10.18632/oncotarget.7525

Figure 5. MiR-222 directly targets ARID1A through the seed sequence at its 3′-UTR region.

Figure 5

(A) Putative seed-matching sites or mutant sites of ARID1A 3′-UTR region with miR-222. (B, C) These ARID1A 3′-UTR luciferase reporter constructs were cotransfected using miR-222 mimics in As-T cells (B) or in BEAS-2B cells (C), and analyzed as above. (D, E) These reporter constructs were cotransfected with anti-miR-222 inhibitor in As-T cells (D) or in A549 cells (E), and analyzed as above. Data are presented as mean ± SE from three independent experiments with three replicates per experiment. **indicates significant difference compared to that of control cells (P < 0.01).