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. 2016 Feb 17;7(14):17854–17869. doi: 10.18632/oncotarget.7439

Figure 7. PI3K/AKT activation contributes to WDR26-regulated breast cancer cell growth and migration.

Figure 7

A-C. effects of PI3K and AKT inhibitors on MDA-MB231 cell growth and migration. MDA-MB231 cells were treated with the indicated PI3K and AKT inhibitors at the indicated doses, and the effects on tumor cell growth in Matrigel (A), cell migration (B) and LPA- and EGF-simulated AKT phosphorylation (C) were determined. *p<0.05 versus untreated control (n=3). GDC(GDC0941), TGX(TGX221), AS(AS605240), IC(IC87114) and MK(MK2206) are inhibitors for pan-PI3K, PI3Kβ, PI3Kγ, PI3Kδ and pan-AKT, respectively. D-E. effects of PI3K inhibitors on the growth (D) and migration (E) of MCF7 cells overexpresssing GFP or WDR26. TGX, TGX221 1μM; GDC, GDC0941 1 μM; CT, control. *** p<0.001 versus GFP control; #p<0.01 versus GFP or WDR26 control (n=3) in D. * p<0.05 versus basal; # p<0.01 versus CT (n=4) in E.