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. 2016 Feb 25;7(14):18021–18035. doi: 10.18632/oncotarget.7694

Figure 4. Overexpression of PLA2G16 decreases sensitivity to anticancer drugs in a dose- and time-dependent manner.

Figure 4

Cells were plated into 96-well plates and incubated with different concentration of doxorubicin (DOX) (A), cisplatin (CDDP) (B) and etoposide (ETP) (C) for 48 hours. Cells were incubated with DOX (D) or CDDP (E) and ETP (F) for different time period before the addition of MTT. The absorbance of 570 nm was measured after 4 hours with MTT. Results are shown as the mean ± SD of three independent experiments and One way ANOVA was used to determine the statistical significance between PLA2G16 overexpression (WT) and empty vector pBABE-puro (CTL) cells ** indicates p < 0.01; *** indicates p < 0.001.