Table 1. Clinical characteristics and differences in MYC, BCL2, BCL6, pSTAT3 and IRF4 changes according to cell of origin type.
| Choi classification (n=275) | Visco-Young classification (n=282) | Hans classification (n=272) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GCB (n=120) | Non-GCB (n=155) | GCB (n=112) | Non-GCB (n=170) | GCB (n=115) | Non-GCB (n=157) | ||||||||||
| Cohort | No | % | No | % | p | No | % | No | % | p | No | % | No | % | p |
| IPI score High (3-5) |
43 of 116 | 37 | 77 of 146 | 53 | 0.011 | 39 of 107 | 36 | 83 of 159 | 52 | 0.011 | 38 of 112 | 34 | 84 of 151 | 56 | <0.001 |
| MYC | |||||||||||||||
| rMYC | 9 of 85 | 11 | 6 of 111 | 6 | 0.176 | 9 of 79 | 11.5 | 6 of 120 | 5 | 0.095 | 9 of 85 | 11 | 6 of 116 | 5 | 0.149 |
| gMYC | 20 of 81 | 25 | 17 of 102 | 17 | 0.179 | 21 of 70 | 28 | 16 of 109 | 15 | 0.03 | 21 of 80 | 26 | 16 of 108 | 15 | 0.051 |
| BCL2 | |||||||||||||||
| rBCL2 | 30 of 79 | 38 | 5 of 104 | 5 | <0.001 | 30 of 78 | 38 | 6 of 107 | 6 | 0.000 | 31 of 80 | 39 | 4 of 105 | 4 | <0.001 |
| gBCL2 | 5 of 77 | 7 | 20 of 101 | 20 | 0.011 | 5 of 76 | 7 | 20 of 104 | 19 | 0.015 | 5 of 77 | 7 | 20 of 103 | 19 | 0.013 |
| BCL6 | |||||||||||||||
| rBCL6 | 11 of 72 | 15 | 38 of 92 | 41 | <0.001 | 11 of 68 | 16 | 39 of 98 | 40 | 0.001 | 12 of 71 | 17 | 38 of 96 | 40 | 0.002 |
| gBCL6 | 15 of 81 | 19 | 15 of 92 | 16 | 0.701 | 13 of 77 | 17 | 17 of 98 | 17 | 0.936 | 15 of 79 | 19 | 15 of 97 | 16 | 0.536 |
| IRF4 | |||||||||||||||
| rIRF4 | 1 of 20 | 5 | 2 of 53 | 4 | 0.623 | 1 of 16 | 6 | 2 of 58 | 3 | 0.524 | 1 of 22 | 4.5 | 2 of 52 | 4 | 0.659 |
| gIRF4 | 0 of 9 | 0 | 4 of 30 | 13 | 0.333 | 0 of 8 | 0 | 4 of 32 | 12.5 | 0.393 | 0 of 10 | 0 | 4 of 30 | 13 | 0.3 |
| DHL MYC/BCL 2+ (n=4) | 4 of 55 | 7 | 1 of 68 | 1.5 | 0.123 | 4 of 55 | 7 | 1 of 70 | 1 | 0.117 | 4 of 55 | 7 | 1 of 70 | 1 | 0.117 |
Abbreviations: GCB: germinal center B-cell-like; DLBCL, diffuse large B-cell lymphoma; rMYC: rearrangement of MYC; gMYC: gain of the MYC locus; rBCL2: rearrangement of BCL2; gBCL2: gain of BCL2 locus; rBCL6 rearrangement of BCL6; gBCL6: gain of BCL6 locus. IPI score ranges from 0 to 5, with 0 indicating the absence of prognostic factors and 5 indicating the presence of all prognostic factors. The IPI score was stratified by the proposed RIPI score. pSTAT3, phosphorylated STAT3 protein expression.