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. 2016 Feb 22;7(14):18247–18261. doi: 10.18632/oncotarget.7570

Figure 3. HGF-induced EMT was inhibited by miR-206 mimics.

Figure 3

A, B. A549 cells and 95D cells were transfected with miR-206 mimics and then stimulated with 50 ng/mL of HGF, epithelial morphology were observed under a light microscope (Bar = 50μm). Meanwhile, western blot analysis showed that miR-206 mimics treatment resulted in high expression of E-cadherin and low expression of vimentin C, D. HGF induced migration and invasion were inhibited by miR-206 mimics. A549 cells and 95D cells were transfected with miR-206 mimics or control sequences, and then treated with 50 ng/mL of HGF. Wound-healing assays and transwell invasion assays were used to investigate the migratory and invasive ability of cells, respectively. Cells were transfected with miR-206 mimics treatment led to inhibition of migration and invasion induced by HGF exposure. Bar = 200μm.* P<0.05, ** P<0.01 vs control.