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. 2016 Feb 22;7(14):18247–18261. doi: 10.18632/oncotarget.7570

Figure 4. miR-206 inhibited HGF-induced activation of PI3k/Akt/mTOR signaling in lung cancer cells.

Figure 4

A, B. Western blot analysis showed that miR-206 downregulated the expression of c-Met, p-Met, p-Akt (ser473) and p-mTOR proteins. Under HGF (20 ng/ml, 15min) stimulation, miR-206 showed more obviously inhibitory effect on PI3k/Akt/mTOR pathway both in A549 cells and 95D cells. Relative protein expression was calculated by gray value of indicated protein/GAPDH. NC: Negative control. * P<0.05, ** P<0.01 vs its control as indicated in Figure.