Table 5. Multivariate analysis for 5-year DFS and OS when pN category enrolled.

Variables	5-Year DFS			5-Year OS
	HR	95.0% CI	P	HR	95.0% CI	P
Age	—	—	—	1.346	(1.160 to 1.563)	<0.0001
Preoperative CEA	0.901	(0.793 to 1.023)	0.108	0.950	(0.822 to 1.099)	0.493
Preoperative CA199	0.976	(0.837 to 1.138)	0.755	0.839	(0.709 to 0.993)	0.041
pT category	1.448	(1.270 to 1.651)	0.000	1.517	(1.300 to 1.769)	<0.0001
npN category	1.519	(1.444 to 1.598)	<0.0001	1.653	(1.560 to 1.752)	<0.0001
TDs	0.665	(0.570 to 0.775)	<0.0001	1.108	(1.007 to 1.202)	0.032
Venous invasion	0.730	(0.595 to 0.897)	0.003	0.791	(0.629 to 0.995)	0.045
Lymphatic invasion	0.466	(0.283 to 0.769)	0.003	0.534	(0.311 to 0.917)	0.023
Differentiation grade	1.333	(1.163 to 1.529)	<0.0001	1.384	(1.187 to 1.613)	<0.0001
Pathological category	1.094	(0.989 to 1.210)	0.082	1.140	(1.108 to 1.277)	0.023
Histological type	0.936	(0.784 to 1.117)	0.463	1.139	(0.947 to 1.371)	0.168
Adjuvant Chemotherapy	—	—	—	1.747	(1.488 to 2.052)	<0.0001