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. 2016 Feb 22;7(14):18309–18324. doi: 10.18632/oncotarget.7579

Figure 2. Potential links between PE5 down-regulated oncogenes and up-regulated tumor suppressors and deregulated metabolic pathways through signaling pathways.

Figure 2

The PE5 down-regulated oncogenes and the PE5 up-regulated tumor suppressors are shown in the blue boxes while the potential signaling pathways are indicated in the empty boxes. The deregulated metabolic pathways are inhibited by both the down-regulation of the oncogenes and the up-regulation of the tumor suppressor (see text for more details). Genes: BCL2L11, BCL2-like 11 (apoptosis facilitator); CLU, clusterin; MET, met proto-oncogene (hepatocyte growth factor receptor); MXD1, MAX dimerization protein 1; NFKBIA, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; TGM2, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); WWOX, WW domain containing oxidoreductase.