Table 3. KEGG pathway annotation of PE5 differentially expressed genes in NCI/ADR-RES cell line.
| KEGG term | Gene count a | % Down-regulated genes | P-value |
|---|---|---|---|
| Lysosome | 14 | 92.86 | 8.84E-05 |
| Metabolic pathways | 59 | 88.14 | 8.73E-04 |
| Pyruvate metabolism | 6 | 66.67 | 2.64E-03 |
| Steroid biosynthesis | 4 | 100.00 | 3.97E-03 |
| Propanoate metabolism | 5 | 80.00 | 5.01E-03 |
| Glycolysis / Gluconeogenesis | 7 | 85.71 | 7.91E-03 |
| Nicotinate and nicotinamide metabolism | 4 | 100.00 | 9.47E-03 |
| Gastric acid secretion | 7 | 71.43 | 1.56E-02 |
| Homologous recombination | 4 | 25.00 | 1.63E-02 |
| Vitamin B6 metabolism | 2 | 100.00 | 1.72E-02 |
| Selenocompound metabolism | 3 | 66.67 | 2.09E-02 |
| Other glycan degradation | 3 | 100.00 | 2.09E-02 |
| Aminoacyl-tRNA biosynthesis | 6 | 100.00 | 2.38E-02 |
| Focal adhesion | 13 | 92.31 | 2.55E-02 |
| Glycosaminoglycan degradation | 3 | 66.67 | 2.83E-02 |
| ECM-receptor interaction | 7 | 100.00 | 3.10E-02 |
| Viral myocarditis | 6 | 66.67 | 3.75E-02 |
| Salivary secretion | 7 | 85.71 | 3.85E-02 |
| Bile secretion | 6 | 50.00 | 3.98E-02 |
a
Number of differentially expressed genes that belong to these terms.