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. 2016 Feb 28;7(14):18356–18370. doi: 10.18632/oncotarget.7786

Figure 5. Combination of elevated SH3BP1 expression and MVD count is a powerful simplified predictor model in poor clinical outcome in HCCs.

Figure 5

A. Elevated SH3BP1 expression in training cohort 2 of 326 paired HCC clinical samples were determined by IHC method (Original magnification, ×400). Based on the results of IHC staining, the expression of SH3BP1 was classified as low expression (IHC score 0 & 1+, n = 46) and high expression (IHC sores 2+ & 3+, n = 280). B. MVD in training cohort 2 HCC tissues was determined by CD105 IHC staining as described in Materials and Methods. Students't test shows that SH3BP1 protein high expression group had the higher MVD than low expression group. C. According to the scale of IHC staining in training cohort 2, higher IS of SH3BP1 in HCC tumors was significantly associated with tumor advanced tumor stage (P < 0.001). D. Kaplan-Meier method estimates of overall survival time and time to recurrence (TTR) to training cohort 2 HCC patients. E. The predictive value of the simplified model existed in cohort 3 of 112 cases. Low risk group: SH3BP1Low/MVDLow; Medium risk group: SH3BP1High/MVDLow or SH3BP1Low/MVDHigh; High risk group: SH3BP1High/MVDHigh. Value of P < 0.05 was considered statistically significant.