Table 2. Multivariable Cox regression analysis of overall survival in training cohort 2 of 326 HCC cases.
| Clinical and pathological indexes | n | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|
| RR (95% CI) | P | RR (95% CI) | P | ||
| Albumin (g/L) | |||||
| >35 | 295 | 1 | 1 | ||
| ≤35 | 31 | 1.73 (1.19-2.32) | 0.027 | 1.73(1.02-2.53) | 0.052 |
| Child-Pugh classification | |||||
| A | 322 | 1 | 1 | ||
| B | 4 | 1.69 (1.07-2.51) | 0.018 | 1.58(1.04-2.49) | 0.066 |
| Preoperative AFP level (ng/mL) | |||||
| ≤ 20 | 167 | 1 | 1 | ||
| > 20 | 159 | 1.82 (1.12-2.58) | 0.035 | 1.76(1.02-2.53) | 0.041 |
| Tumor nodule number | |||||
| Single | 181 | 1 | 1 | ||
| Multiple * | 145 | 1.62 (1.07-2.76) | 0.028 | 1.56(1.05-2.57) | 0.063 |
| Tumor encapsulation | |||||
| Presence | 138 | 1 | — | — | |
| Absence | 188 | 1.72 (1.04-2.83) | 0.033 | — | — |
| Edmondson-Steiner grade | |||||
| I – II | 253 | 1 | — | — | |
| III – IV | 73 | 1.72 (1.03-2.87) | 0.037 | — | — |
| Vascular invasion§ | |||||
| Absence | 156 | 1 | 1 | ||
| Presence | 170 | 1.75 (1.15-2.65) | 0.009 | 1.32(1.01-2.38) | 0.017 |
| TNM stage | |||||
| I | 153 | 1 | 1 | ||
| II–III | 173 | 1.65 (1.09-2.52) | 0.019 | 1.59(1.01-2.50) | 0.045 |
| SH3BP1 expression | |||||
| Low | 46 | 1 | 1 | ||
| High | 280 | 1.97 (1.28-3.09) | 0.003 | 1.69(1.02-2.72) | 0.008 |
| MVD | |||||
| ≤65.5 | 137 | 1 | 1 | ||
| > 65.5 | 189 | 1.62 (1.04-2.53) | 0.028 | 1.43(1.02-2.33) | 0.003 |
Abbreviations: RR, risk ratio; HBsAg, hepatitis B surface antigen; AFP, a-fetoprotein; TNM, tumor-node-metastasis staging; MVD, microvessel density.
*
Multiple was defined as: tumor number > 2.
§
Vascular invasion (VI) was defined as: gross invasion and microscopic invasion involving portal vein, hepatic vein, inferior vena cava (IVC).