Figure 1. Mutation landscape in lung squamous cell carcinoma (LSCC) of smoking and never-smoking patients.

(A) A heat map of significant genetic events in 37 LSCC patients is provided for both genes previously implicated in lung squamous cell carcinoma and novels genes found to be recurrently altered in the present study. Events, including non-synonymous, stop-gain point mutations and truncation mutations are color coded according to the legend provided. Each column denotes an individual normal/tumor paired patients, and each row represents a gene. The left panel shows the mutation frequency in each gene. (B) A similar heat map of mutations found only in smokers or never-smokers.