Table 1. Genetic variants shared in parental gastric cancer cell lines.
| Cell lines | gene | variant | localization | variant effect | protein change | annotation | Functional prediction score (HVAR, SIFT, MutationAssessor) |
|---|---|---|---|---|---|---|---|
| AKG KKP | HER2 | c.C3508G | exonic | nonsynonymous SNV | p.P1170A | rs1058808 | P, D, M |
| HER3 | c.-277T>C | upstream | - | - | rs7297175 | - | |
| IVS2+8A>T | intronic | - | - | rs2271194 | - | ||
| HER4 | IVS16-23insA | intronic | - | - | rs202070359 | - | |
| AKG NCIN87 | HER4 | IVS12-15T>C | intronic | - | - | rs4673628 | - |
| AKG KKP NCIN87 | HER3 | c.-211delCT | UTR5 | - | - | - | - |
| c.C2270A | exonic; splicing | nonsynonymous SNV | p.T757K | - | D, D, N | ||
| HER4 | IVS17-60delAG | intronic | - | - | rs146953835 | - | |
| IVS17-102insG | intronic | - | - | rs76332141 | - | ||
| IVS7-7delT | intronic | - | - | rs67894136 | - |
HVAR outputs: P, potentially deleterious; D, probably deleterious; SIFT outputs: D, deleterious; MutationAssessor outputs:, N, neutral; M, medium; -, unknown