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. 2016 Mar 4;7(14):18694–18704. doi: 10.18632/oncotarget.7909

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Copyright: © 2016 Atiq et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Suppression of HT29 cell growth (48 h) by MEDICA is abrogated by infected shB-Raf(V600E). Mean ± SD. *Significant as compared to respective control. ^#Significant as compared to respective scramble. (B) MEDICA-induced p21 and cleaved PARP in HT29 cells is abrogated by infected shB-Raf(V600E). (C) Suppression of EGF-activated EGFR, Akt and Erk in HT29 cells by MEDICA is abrogated by infected shB-Raf(V600E). (D) Suppression of EGF-activated EGFR and Akt in HT29 cells by MEDICA is abrogated by inhibiting MEK by U0126. (E, F) Suppression of IL-6-activated STAT3 in HT29 cells by MEDICA is abrogated by infected shB-Raf(V600E), or upon inhibiting MEK by U0126 or PD0325901. (G) Suppression of constitutive STAT3 and Erk in A375 cells by MEDICA is abrogated by inhibiting B-Raf(V600E) by PLX4032, or by inhibiting MEK by PD0325901. (B-G) Representative blots.