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. 2016 Mar 4;7(14):18694–18704. doi: 10.18632/oncotarget.7909

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Copyright: © 2016 Atiq et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A, B) MEDICA activates Erk and its downstream targets RSK(Thr359/Ser363), LKB1(Ser428), CREB(Ser133), EGFR(Thr669), STAT3(Ser727), FAK(Ser910) and IRS1(Ser636/639), while inhibiting basal Akt(Ser473). (C) shRNA B-Raf(V600E) or U0126 abrogates EGFR(Thr669) phosphorylation and inhibition of basal Akt(Ser473) by MEDICA (HT29 cells). (D) Activation of Erk and its canonical downstream targets by MEDICA is MEK-independent (HT29 cells). (E) Growth suppression, Akt inhibition and apoptosis by MEDICA are AMPK-independent (HT29 cells). (A-E) Representative blots.