Table 3. Cox proportional hazard modeling of event-free survival.
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age ≥ 18 months | 4.6 | 1.5–13.7 | 0.006 | 0.8 | 0.2–2.8 | 0.741 |
| Stage 4 | 10.1 | 2.4–45.6 | 0.002 | 7.4 | 1.5–35.4 | 0.012 |
| MYCN amplification | 4.0 | 1.6–10.1 | 0.004 | 4.2 | 1.5–11.9 | 0.006 |
| IDRF+ | 2.1 | 0.8–5.7 | 0.145 | 0.6 | 0.2–1.8 | 0.382 |
| PET-UHR | 6.9 | 2.3–20.8 | 0.001 | 4.9 | 1.4–16.9 | 0.012 |
| FDGhi (SUVmax ≥ 3.31) | 8.1 | 1.9–35.0 | 0.005 | |||
| FDOPAlo (SUVmax < 4.12) | 7.5 | 1.8–32.4 | 0.007 | |||
| Higher G:D ratio (≥ 1.09) | 6.3 | 2.1–19.2 | 0.001 | |||
Abbreviations: 95%CI = 95% confindence interval; HR = hazard ratio; IDRF+ = presence of image-defined risk factor(s); PET-UHR = ultra-high-risk tumor uptake pattern on FDG and FDOPA PET, defined as FDG SUVmax ≥ 3.31 and FDOPA SUVmax < 4.12.