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. 2016 Mar 1;7(14):18919–18926. doi: 10.18632/oncotarget.7810

Figure 3. The relationship between smoking and oxidative DNA damage response.

Figure 3

A. The levels of 8-OHdG in BALF was significant higher in smokers than nonsmokers both in lung cancer patients (6.8 ± 0.9 ng/ml versus 3.2 ± 0.6 ng/ml, P = 0.0049) and noncancer controls (3.0 ± 0.6 ng/ml versus 1.2 ± 0.2 ng/ml, P = 0.0227). B. Representative examples of immunohistochemistry of 8-OHdG expression in smokers and nonsmokers. C. Quantification of 8-OHdG expression in the lung of smoking and nonsmoking patients with lung cancer (62.7 ± 7.7 % versus 29.8 ± 4.0 %, P = 0.0035) and noncancer controls (38.5 ± 4.1% versus 7.5 ± 2.2 %, P = 0.0004). D. Statistically correlation was observed between levels of 8-OHdG and smoking index (r = 0.5241, P < 0.0001). Values in the bar graphs are given as mean ± SEM; BALF, bronchoalveolar lavage fluid.