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. 2016 Mar 1;7(14):18919–18926. doi: 10.18632/oncotarget.7810

Figure 4. Receiver operating characteristic (ROC) curve was performed to evaluate the threshold value of 8-OHdG in differentiating lung cancer from benign diseases.

Figure 4

A. With a cut-off value of 2.86 pg/ml, 8-OHdG reached a sensitivity of 70.0%, 95% CI (55.4%, 82.1%), a specificity of 73.7%, 95% CI (56.9%, 86.6%). The area under the curve (AUC) was 0.7363, 95% CI (0.6323, 0.8404). B–C. According to ROC analysis, the cut-off levels of 8-OHdG in BALF for smokers and nonsmokers was 3.23 ng/ml and 1.885 ng/ml, respectively, and the corresponding sensitivity and specificity were 77.4% (95% CI, 58.9%-90.4%) and 60.9% (95% CI, 38.5%-80.3%), 63.2% (95% CI, 38.4%-83.7%) and 80.0% (95% CI, 51.9%-95.7%), respectively. Additionally, AUC for smokers and nonsmokers was 0.7532 (95% CI, 0.6246-0.8817) and 0.7404 (95% CI, 0.5662-0.9145), respectively.