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. 2016 Mar 1;7(14):18927–18939. doi: 10.18632/oncotarget.7816

Figure 5. SIRT2 regulates p27 levels through Skp2-mediated p27 degradation.

Figure 5

The SIRT2-depleted A549 cells were exposed with MG132, a specific proteasome inhibitor to reduce the cellular degradation of ubiquitin-conjugated proteins. A. The levels of SIRT2, Skp2 and p27 in SIRT2-depleted A549 cells with/with MG132 were analyzed by Western blot, shown by representative Western blot. B–D. Quantification for SIRT2 (B), Sep2 (C) and p27 (D) protein in SIRT2-modified A549 cells. *p<0.05. NS: non-significant. N=5.