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. 2016 Mar 8;7(14):19018–19030. doi: 10.18632/oncotarget.7968

Figure 8. ZLM-7 inhibited tumor growth and neoangiogenesis in MCF-7 breast cancer xenografts.

Figure 8

Animals were treated with 15 mg/kg ZLM-7 or CA-4 daily. A. Anti-tumor effects of ZLM-7 and CA-4 on MCF-7 bearing mice. B. In vivo tumor growth inhibition activity of ZLM-7 and CA-4. C. Change in body weight of mice. D. CD31 immunohistochemistry staining tumor tissues (bar = 20 μm). E. Quantitative analysis of tumor section stained with CD31. F. HE staining of tumor tissues (10×, bar = 20 μm). G. HE staining of liver, spleen and kidney (10×, bar = 20 μm). H. Immunohistochemical detection with specific antibodies against HIF-1α, VEGFA and VEGFR2 (40×, bar = 20 μm). Data were represented as means ± SD, n=5, *P < 0.05 versus control.