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. 2016 Jul 19;11:338. doi: 10.1186/s11671-016-1554-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — HBc-specific IgG antibody titers (reciprocal serum dilution) induced by HBc VLPs, CpG@HBc VLPs, CpG-Au@HBc VLPs, CpG-Au + HBc VLPs, CFA/IFA + HBc VLPs, and PBS in BALB/C mice, respectively. Mice (n = 6) were intraperitoneally vaccinated on days 0, 7, 14, and 21 as described in the “Methods” section and detected antibody titers at the end of each week. The results represent anti-HBc titers as the means from six mice ± standard deviation (SD). The statistical significance of the results was analyzed (PBS group served as control, all the other groups contrasted with PBS group) and indicated: *p < 0.05; **p < 0.01