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. 2016 Jul 19;11:338. doi: 10.1186/s11671-016-1554-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Induction of HBc-specific CD4⁺ and CD8⁺ T cells after immune with HBc VLPs, CpG@HBc VLPs, CpG-Au@HBc VLPs, CpG-Au + HBc VLPs, CFA/IFA + HBc VLPs, and PBS, respectively. The splenocyte surface molecules expressions were determined with flow cytometry analysis. A representative result of three independent experiments was shown in (a); the data shown in (b) and (c) were determined as means ± SD from three experiments. The statistical significance of the results was analyzed and indicated: *p < 0.05. ns no significant difference