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. 2016 Jul 19;11:338. doi: 10.1186/s11671-016-1554-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — The secretion level of cytokines a IFN-γ, b IL-4, and c IL-2 in serum of BALB/c mice after immunization with HBc VLPs, CpG@HBc VLPs, CpG-Au@HBc VLPs, CpG-Au + HBc VLPs, CFA/IFA + HBc VLPs, and PBS, respectively. The data shown is a representative of the three independent experiments, and the statistical significance of the results was analyzed and indicated *p < 0.05; **p < 0.01. ns no significant difference