Table 1. Clinical Trials of Vaccines for RSV Infection.
| Vaccine | Age (yrs) | Developer | Phase | Reference | |
|---|---|---|---|---|---|
| Type | Antigen | ||||
| Live-attenuated | RSV-PIV3 chimeric virus (MEDI-534) | 0.2-9 | MedImmune | 1, 2 | Gomez, et al.57; Bernstein, et al.58; Yang, et al.59 |
| rA2cp248/404/1030ΔSH (MEDI-559) | 0.4-2 | MedImmune | 1, 2 | Schickli, et al.60; Malkin, et al.61 | |
| RSV MEDI ΔM2-2 | 0.5-49 | NIAID | 1 | Bermingham and Collins62; Karron, et al.63 | |
| RSV ΔNS2 Δ1313 I1314L | 0.5-5 | NIAID | 1 | Luongo, et al.64 | |
| rA2cp248/404/1030ΔSH containing five independent attenuating elements | 0.5-2 | NIAID | 1 | Luongo, et al.65 | |
| RSV LID ΔM2-2 | 0.5-2 | NIAID | 1 | ||
| M2-2 deleted RSV (D46cpΔM2-2) | 0.5-5 | NIAID | 1 | Karron, et al.63 | |
| Subunit | RSV-F | 2-6, 18-49, >60 | Novavax | 1, 2, 3 | Calder, et al.66; Collins and Mottet67; López, et al.68; Glenn, et al.69 |
| RSV-sF/GLA (MEDI-7510) | >60 | MedImmune | 1, 2 | ||
| RSV F | 18-45 | Novartis | 1 | ||
| RSV-SHe/DepoVaxTM and alum | 50-64 | Dalhousie University, ImmunoVaccine Technologies | 1 | https://www.imvaccine.com/infectvac.php | |
| Vectored | Chimpanzee Adenovirus and Modified Vaccinia Ankara encoding the F, N, and M2-1 proteins of RSV (PanAd3-RSV, MVA-RSV) | 18-75 | ReiThera Srl | 1 | Pierantoni, et al.70 |
| Adenovirus encoding full length RSV F protein (Ad26.RSV.FA2 & Ad35.RSV.FA2) | 18-50 | Crucell Holland BV | 1 | Widjojoatmodjo, et al.71 | |
| Chimpanzee Adenovirus encoding RSV protein (ChAd155-RSV; GSK3389245A) | 18-45 | GSK | 1 | http://www.gsk-clinicalstudyregister.com/study/201974#ps | |
| Modified Vaccinia Ankara encoding two surface proteins of RSV (MVA-mBN294B) | 18-65 | Bavarian Nordic | 1 | http://www.bavarian-nordic.com/ | |
| Immuno-stimulant | GSK3003891A | 18-45 | GSK | 1, 2 | http://www.gsk-clinicalstudyregister.com/compounds/gsk3003891a#ps |
RSV, respiratory syncytial virus; PIV3, parainfluenza virus type 3; cp, cold-passaged; NIAID, National Institute of Allergy and Infectious Diseases; GSK, GlaxoSmithKline.