Table 2. Univariate Analysis of Prognostic Factors in Patients Who Received Re-Irradiation.
| Variable | No. of patients | OS (month) | |
|---|---|---|---|
| Median (95% CI) | p value | ||
| Sex | 0.623 | ||
| Male | 19 | 12 (7-17) | |
| Female | 17 | 10 (8-12) | |
| Age (yrs) | 0.494 | ||
| <40 | 14 | 11 (8-14) | |
| ≥40 | 22 | 11 (8-14) | |
| KPS | <0.001 | ||
| <70 | 19 | 8 (5-11) | |
| ≥70 | 17 | 21 (12-30) | |
| WHO grade at recurrence | 0.748 | ||
| I/II | 7 | 13 (10-16) | |
| III | 8 | 11 (8-14) | |
| IV | 21 | 10 (6-14) | |
| Salvage surgery | 0.768 | ||
| No | 9 | 12 (9-15) | |
| Yes | 27 | 11 (8-14) | |
| Dose of re-RT | 0.040 | ||
| <45 Gy | 18 | 10 (8-12) | |
| ≥45 Gy | 18 | 13 (9-28) | |
| Chemotherapy | 0.783 | ||
| No | 17 | 11 (10-12) | |
| Yes | 19 | 12 (6-18) | |
| MGMT methylation status at recurrence | 0.746 | ||
| Methylated | 7 | 8 (6-10) | |
| Unmethylated | 8 | 12 (6-17) | |
| Length of time until RT (month), continuous | 0.040 | ||
CI, confidence interval; OS, overall survival; KPS, Karnofsky performance status; re-RT, re-irradiation; RT, radiation therapy; MGMT, O6-methylguanine-DNA methyltransferase.