Table 3. Multivariate Analysis of Prognostic Factors in Patients Who Received Re-Irradiation.
| Variable | OS (month) | ||
|---|---|---|---|
| HR | 95% CI | p value | |
| Age (≥40 yrs vs. <40 yrs) | 0.8 | 0.3-1.7 | 0.498 |
| KPS (<70 vs. ≥70) | 3.1 | 1.1-8.7 | 0.030 |
| Salvage surgery (no vs. yes) | 1.6 | 0.5-4.5 | 0.410 |
| Dose of re-RT (≥45 Gy vs. <45 Gy) | 0.6 | 0.3-2.0 | 0.589 |
| MGMT methylation status at recurrence (unmethylated vs. methylated) | 1.3 | 0.3-4.6 | 0.719 |
| Time interval between RT (month), continuous | 0.8 | 0.7-0.9 | 0.048 |
CI, confidence interval; HR, hazards ratio; OS, overall survival; KPS, Karnofsky performance status; re-RT, re-irradiation; RT, radiation therapy; MGMT, O6-methylguanine-DNA methyltransferase.