Table 1. Characteristics of Studies Included in the Meta-Analysis.
| Author | Year | Country | Age (mean±SD) | Gender (M/F) | Genotyping methods | Genotype (case/control) | HWE | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | Case | Control | Total | *1/*1 | *1/*2 | |||||
| Chao, et al.8 | 1994 | China | 55.0±3.0 | NR | 27/0 | 50/0 | PCR-directed mutagenesis | 27/50 | 22/44 | 5/6 | 0.652 |
| Chao, et al.9 | 1997 | China | 50.7±12.9 | 49.9±10.6 | 71/4 | 19/0 | PCR-directed mutagenesis | 75/19 | 65/15 | 10/4 | 0.608 |
| Chao, et al.10 | 2000 | China | 50.5±12.6 | 40.8±11.0 | 115/5 | 78/9 | PCR-directed mutagenesis | 116/87 | 98/67 | 18/20 | 0.226 |
| Chao, et al.11 | 2003 | China | 50.0±12.7 | 44.7±9.5 | 150/9 | 35/0 | PCR-directed mutagenesis | 159/35 | 130/28 | 29/7 | 0.511 |
| Kee, et al.12 | 2003 | Korea | NR | NR | NR | NR | PCR-RFLP | 30/12 | 28/9 | 2/3 | 0.621 |
| Kim, et al.13 | 2004 | Korea | 48.8±18.8 | 49.2±20.3 | 19/3 | 44/56 | PCR-RFLP | 22/100 | 17/58 | 5/30 | 0.017 |
| Lee, et al.14 | 2001 | Korea | 52.2±9.3 | 51.7±10.1 | 56/0 | 52/0 | PCR-RFLP | 56/52 | 52/50 | 4/2 | 0.888 |
| Nagata, et al.15 | 1999 | Japan | NR | NR | NR | NR | PCR-SSCP | 27/28 | 25/21 | 2/7 | 0.450 |
| Nagata, et al.16 | 2002 | Japan | NR | NR | NR | 76/68 | PCR-SSCP | 44/29 | 42/26 | 2/3 | 0.769 |
| Yamauchi, et al.17 | 1995 | Japan | 53.0±1.1† | NR | 46/0 | 34/0 | PCR-RFLP | 46/34 | 30/29 | 16/5 | 0.644 |
| Yamauchi, et al.18 | 1995 | Japan | 53.0±1.2† | NR | 42/0 | 34/0 | PCR-RFLP | 42/34 | 30/29 | 12/5 | 0.644 |
| Yokoyama, et al.19 | 2013 | Japan | 55.4±0.5† | 56.5±0.2† | 359/0 | 1543/0 | PCR-RFLP | 359/1543 | 316/1288 | 43/255 | 0.000 |
HWE, Hardy-Weinberg equilibrium; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; PCR-SSCP, polymerase chain reaction-singlestrand conformation polymorphism; NR, not reported.
†Mean±SE.