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. 2016 May 26;468:1419–1432. doi: 10.1007/s00424-016-1836-3

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — A significant FSK-induced I _sc response after NKCC1, ENaC and CA inhibition only seen in WT, not in NBCe1 KO cecal mucosa. a, b After application of luminal amiloride (10⁻⁵M), serosal bumetanide (10⁻⁴M), and bilateral acetazolamide (10⁻⁴M), FSK elicited a residual I _sc response in NBCe WT but not KO cecum. c Since no concomitant J _HCO3 ⁻ response was observed, the I _sc response is indicative of electrogenic NBCe1-dependent Cl⁻ secretion in the WT cecum (n = 9)