Fig. 7.

I _sc changes in response to luminal addition of GlySar in NBCe1 KO and WT jejunum. a I _sc was significantly higher in NBCe1 KO than WT jejunum, also under voltage clamp conditions, in the absence of any ion gradients; 20 mM GlySar caused a biphasic I _sc response. b The initial rapid increase in I _sc was significantly higher in the NBCe1 KO jejunum, indicating that the electrogenic influx of base via the basolateral membrane lowered the I _sc response due to electrogenic H⁺/dipeptide influx via the apical membrane. c The I _sc plateau, however, was significantly reduced in NBCe1 KO jejunum. *P < 0.05, n = 7 KO, 9 WT