Table 2.
FSK-induced I sc response and resistance change in the duodenal, jejunal, cecal, and proximal colonic mucosa of NBCe1 WT and KO mice
| PD (mv) | R t (Ώ cm2) | |||
|---|---|---|---|---|
| Basal | Peak FSK + IBMX | Basal | Peak FSK + IBMX | |
| Duodenum NBCe1+/+ | 0.34 ± 0.15** | 5.78 ± 0.53 | 24.4 ± 1.60 | 43 ± 6.81 |
| Duodenum NBCe1−/− | 1.56 ± 0.09 | 5.66 ± 0.17 | 25.8 ± 2.01 | 44 ± 2.62 |
| Jejunum NBCe1+/+ | 1.28 ± 0.12* | 7.18 ± 0.36 | 23 ± 1.12 | 40.83 ± 3.25 |
| Jejunum NBCe1−/− | 1.66 ± 0.04 | 4.73 ± 0.37* | 22.5 ± 1.25 | 25 ± 1.96# |
| Cecum NBCe1+/+ | 4.14 ± 0.38* | 12.76 ± 1.04 | 43.55 ± 0.89 | 35.78 ± 1.21 |
| Cecum NBCe1−/− | 8.35 ± 0.99 | 13.16 ± 2.19 | 53.88 ± 6.94 | 49.2 ± 6.50 |
| Prox. colon NBCe1+/+ | 3.78 ± 0.52 | 10.38 ± 1.33 | 68.4 ± 1.80 | 89.2 ± 6.01 |
| Prox. colon NBCe1−/− | 2.92 ± 0.67 | 10.72 ± 0.47 | 66.75 ± 6.62 | 77.5 ± 6.91 |
For PD: *P < 0.05; **P < 0.01. For R t: #P < 0.05, n = 6–8